- Data Scientist
- Bioinformatician
- Software Engineer
- Dublin
My name is Andreas and I am a postdoctoral researcher with strong computational background and primary focus on studying apoptosis in cancer cells. Additional research areas include mathematical modelling of signalling pathways such as the unfolded protein response. I am currently working at the Royal College of Surgeons in Dublin as part of a multi-international and –disciplinary group. I am an enthusiastic data scientist, bioinformatician, software engineer and avid problem-solver.
As bioinformatician, I bridge computational biology with experimental research to drive cancer therapy and to deepen our understanding of biological systems.
This comprises collaboration with experimentalists and clinicians to collect and harmonize data, and to design experiments to calibrate and test computational predictions. My full professional proficiency covers, but is not limited to, discovery data analysis, biostatistics, data mining, machine learning, deep learning, clustering, spatial analysis, high-throughput biological datasets, mathematical models, algorithms, databases and software development. Latter include programming in Java, C/C++, R, Python, Perl, Bash and others.
We're flooding people with information. We need to feed it through a processor. A human must turn information into intelligence or knowledge.Grace Hopper
Data Scientist
Data can help reshape the future and I find myself loving the thrill of diving into challenging analysis. My first goal is that my research leaps beyond expectations and to deliver results to a high standard.
Bioinformatician
I have a strong passion for Life Science, with experience in medical research and the ability to breakdown and clearly define problems. I am highly-skilled and experienced in applying computational algorithms and statistical methods to data, and in combining analytic methods with advanced data visualizations.
Problem Solver
I look upon problems as exciting challenges with an unmatched curiosity to learn and grow with new challenges. It is plain fun to gain new perspectives and think outside the box.
Software Engineer
I am an experienced software engineer with attention to details. With my knowledge about of software development life cycle, algorithms and high-performance implementations, I thrive to deliver simple, reliable and elegant solutions.
Work Experience
Post-Doctoral Researcher
Jan 2014 - today
A brief summary will be available on my research page soon.
Visiting Researcher
Jun - Jul 2014
Siemens Austria, Vienna
Two month exchange for pathway modelling and software development as part of the OXY-SENSE project funded by the European Union’s Seventh Framework Programme.
Student Employee: Software Developer
Mar - Sep 2009
As a part time JAVA software developer I was responsible for JSP front end, as well as, data transfer protocol and server support tool development for the back end.
Student Employee: Software Developer
Feb 2008 - Feb 2009
As student intern and part time JAVA software developer I was responsible for the development of the costumer client KURDT to electronically transfer clinical reports to costumers. Further, I took part in the daily IT helpdesk, administration and supported the team with the development of software tools and various scripts.
Education
Dipl.-Ing. (FH) Bioinformatics, Software Engineering
Sept 2006 - Jul 2010
Undergraduate program that combined modern information sciences with life sciences and engineering. Equivalent to a bachelor's / master's degree.
Fachinformatiker, Anwendungsentwicklung
Jan 2003 - Sep 2020
IT specialist dual-education apprenticeship (Berufsausbildung) with focus on software development. At Vocatus I was responsible for the development various software solution (JAVA, VBasic, ASP, Perl), administration and IT help desk support.
Peer-reviewed journal publications
- Lindner AU et al. Systems analysis of protein signatures predicting Cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenografts models of metastatic colorectal cancer Int J Cancer. 2020 32700762
- Lindner AU et al. Systems biology analysis identifies molecular determinants of chemotherapy-induced diarrhoea J Mol Med (Berl). 2020 31848663
- Lucantoni F et al. Systems modeling accurately predicts responses to enotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells Cell Death Dis. 2018 29352235
- Lindner AU et al. BCL-2 system analysis identifies high-risk colorectal cancer patients Gut. 2017 27663504
- Lindner AU et al. Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers J Mol Med (Berl). 2018 30069746
- Ryan D et al. Calnexin, an ER stress-induced protein, is a prognostic marker and potential therapeutic target in colorectal cancer J Transl Med. 2016 27369741
- Lindner AU et al. The indirect activation model of mitochondrial outer membrane permeabilisation (MOMP) initiation requires a trade-off between robustness in the absence of and sensitivity in the presence of stress - PubMed.html Mol Biosyst. 2013 23824068
- Schmid J et al. Systems analysis of cancer cell heterogeneity in caspase-dependent apoptosis subsequent to mitochondrial outer membrane permeabilization J Biol Chem. 2012 23038270
- Lindner AU et al. Systems analysis of BCL2 protein family interactions establishes a model to predict responses to chemotherapy Cancer Res. 2013 23329644
- Flanagan L et al. BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer J Mol Med (Berl). 2015 25388617
- Flanagan L et al. High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer Radiat Oncol. 2015 26071313
- Salvucci M et al. A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer Clin Cancer Res. 2017 27649552